Should an unrelated marrow donor search be initiated anyway if my child has no related donor?

Transplantation form unrelated donors (bone marrow or cord blood) in Thalassemia generally requires extended compatibility and thus the chances of finding a suitable unrelated donor are not very high especially if the ethnic background is underrepresented in bone marrow donor registries. Unrelated transplant is more risky and much more expensive than either matched-related (from a compatible sibling) or partioally matched-related (haploidentical) donor. C2C does not recommend unrelated BMT for thalassemia.

These answers have been prepared by:
- Dr. Lawrence Faulkner, Cure2Children medical team coordinator
- Dr. Sadaf Khalid, Cure2Children Pakistan branch coordinator